Pyruvate dehydrogenase complex (PDHC) deficiencies are a group of mainly infantile onset disorders stemming from defects in pyruvate catabolism. They are characterised by severe lactic acidosis and progressive neurodegeneration. Although the PDHA1 gene is implicated in most cases of PDHC deficiency worldwide. no pathogenic variants have been reported in South African patients to date. https://parisnaturalfoodes.shop/product-category/balsam-fir/