DNA methylation at CG sites is important for gene regulation and embryonic development. In mouse oocytes. de novo CG methylation requires preceding transcription-coupled histone mark H3K36me3 and is mediated by a DNA methyltransferase DNMT3A. DNMT3A has a PWWP domain. https://www.danddcollectiblers.shop/product-category/prenatal-care/